GrippeCanadaV3, Main, Exploration, bibRecord, 000197

Microneutralization assay titres correlate with protection against seasonal influenza H1N1 and H3N2 in children.

Identifieur interne : 000197 ( Main/Exploration ); précédent : 000196; suivant : 000198

Microneutralization assay titres correlate with protection against seasonal influenza H1N1 and H3N2 in children.

Auteurs : Chris P. Verschoor [Canada] ; Pardeep Singh [Canada] ; Margaret L. Russell [Canada] ; Dawn M E. Bowdish [Canada] ; Angela Brewer [Canada] ; Louis Cyr [Canada] ; Brian J. Ward [Canada] ; Mark Loeb [Canada]

Source :

PloS one [ 1932-6203 ] ; 2015.

RBID : pubmed:26107625

Descripteurs français

English descriptors

KwdEn :
- Adolescent, Alberta, Antibodies, Viral (blood), Antibody Formation (immunology), Child, Child, Preschool, Hemagglutination Inhibition Tests, Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Immunity, Humoral (immunology), Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza Vaccines, Influenza, Human (immunology), Manitoba, Neutralization Tests, Polymerase Chain Reaction, Prospective Studies.
MESH :
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Hemagglutinin Glycoproteins, Influenza Virus.
- geographic : Alberta, Influenza Vaccines, Manitoba.
- immunology : Antibody Formation, Immunity, Humoral, Influenza, Human.
- Adolescent, Child, Child, Preschool, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Neutralization Tests, Polymerase Chain Reaction, Prospective Studies.

Abstract

Although the microneutralization (MN) assay has been shown to be more sensitive than the hemagglutination inhibition (HAI) assay for the measurement of humoral immunity against influenza viruses, further evidence relating MN titres to protective efficacy against infection is needed. Serum antibodies against seasonal H1N1 and H3N2 influenza were measured in children and adolescents (n = 656) by MN and hemagglutination inhibition (HAI) assays. Compared to HAI, the MN assay is more sensitive in detecting serum antibodies and estimates of protective effectiveness against PCR-confirmed infection were higher for both subtypes. Given our findings, the MN assay warrants further consideration as a formal tool for the routine evaluation of vaccine-induced antibody responses.

DOI: 10.1371/journal.pone.0131531
PubMed: 26107625

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000201
to stream Main, to step Curation: 000201

Le document en format XML

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<front><div type="abstract" xml:lang="en">Although the microneutralization (MN) assay has been shown to be more sensitive than the hemagglutination inhibition (HAI) assay for the measurement of humoral immunity against influenza viruses, further evidence relating MN titres to protective efficacy against infection is needed. Serum antibodies against seasonal H1N1 and H3N2 influenza were measured in children and adolescents (n = 656) by MN and hemagglutination inhibition (HAI) assays. Compared to HAI, the MN assay is more sensitive in detecting serum antibodies and estimates of protective effectiveness against PCR-confirmed infection were higher for both subtypes. Given our findings, the MN assay warrants further consideration as a formal tool for the routine evaluation of vaccine-induced antibody responses. </div>
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Microneutralization assay titres correlate with protection against seasonal influenza H1N1 and H3N2 in children.

Microneutralization assay titres correlate with protection against seasonal influenza H1N1 and H3N2 in children.

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